Things go from bad to worse as Brain Drain is still missing, and the greatest villains in Marvel history team up to take out the one thing that's stood in their way: our hero, Doreen Green!

With Melissa doing everything she can to destroy Squirrel Girl, is there anything Doreen can do to survive??

Gosh, I sure hope so because it'd be nice if we actually make it to #50 BUT TECHNICALLY YOU NEVER KNOW!!

Especially when Squirrel Girl's first villain, DOCTOR DOOM, is involved...

I don't want to say more because SPOILERS, but trust us when we say this is a bonkers issue in which bonkers things happen, and you should definitely order it right now!!